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Tafasitamab-cxix is a CD19-directed monoclonal antibody that selectively targets malignant B cells associated with diffuse large B-cell lymphoma (DLBCL). Used in combination with lenalidomide, it strengthens the body's immune response against lymphoma cells and promotes their destruction. For eligible patients with relapsed or refractory disease, treatment is intended to support disease control, prolong response duration, and help maintain meaningful clinical outcomes.