When choosing or editing a gaming or anime PFP, focus on a strong silhouette...

https://super-wiki.win/index.php/What_Makes_a_Character_Silhouette_Stand_Out_as_a_Tiny_Profile_Icon%3F

When choosing or editing a gaming or anime PFP, focus on a strong silhouette and high contrast to keep it clear at small sizes. Crop tightly around the face and use a simple background without text to avoid clutter